Pack of 24 Vagifem 10 microgram vaginal tablets

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Vagifem are vaginal tablets used to treat the symptoms of menopause. They contain oestrogen and are a type of 'hormone replacement therapy' (HRT).

You can place new and repeat reorders for your medication online. Complete a short assessment with us and your Superdrug Online Doctor can check if treatment is right for you.

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To place an order, fill in a brief questionnaire. One of our doctors will review your order and prescribe a suitable treatment.

Vagifem – 24 tablets £50.00

Price includes standard delivery or click and collect.

In a hurry? Choose Click and Collect and pick up your order after just 4 hours from a Superdrug Pharmacy.

Delivery options

Delivery method Cost Estimated delivery

You will choose your delivery option at the checkout. Delivery options may vary depending on the pack size and dosage chosen.

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About Vagifem

What is Vagifem? – it is a tablet used to treat the changes that happen in and around the vagina following the menopause. Specifically – the symptoms of vaginal dryness or irritation (known as vaginal atrophy).

Vagifem contains estradiol, a synthetic hormone belonging to the group of hormones called oestrogens. It is used to treat vaginal atrophy, which is caused by drop in the levels of oestrogen in your body. 

How does it work? – the treatment works by replacing the oestrogen which would be produced naturally by your ovaries before the menopause. Vagifem comes in tablet form, and is inserted directly into the vagina, so that it provides immediate relief to discomfort in that area. 

Many people prefer to take hormones in tablet form for several reasons: 

  • It’s a safe and effective form of medical treatment
  • The fact that is a localised treatment (only affecting the immediate area) means that there should be no full body side effects of the hormones, unlike other forms of hormone replacement therapy (HRT) or hormonal contraceptives like the contraceptive pill

Vaginal tablets are very easy to use, and come with an applicator and instructions to guide you through insertion. Your nurse or GP can show you how to use this the first time, if you are unsure about it. 

You can buy Vagifem online using an online doctor service, like Superdrug – your online doctor will check your assessment, your medical history, and suitability of treatment. You should be ok to reorder, as long as your treatment is still working well for you.

Use a trusted service – it’s very important to use a safe and registered online doctor service, like Superdrug. Our online doctor service is run by licensed medical professionals. Don’t ever order medicines from an unregulated website that you can’t trust, because unlicensed drugs can be unsafe and dangerous to your health.

A doctor assessment will tell you – you can use Vagifem if a doctor decides that it is safe for you to do so. It is used to relieve symptoms like vaginal dryness or irritation in people who have experienced the menopause. 

Contraindications – you should not use Vagifem if you:

  • Currently have, or have had, cancer of the breast or uterus
  • Have any unusual vaginal bleeding
  • Have had a heart attack or stroke
  • Currently have, or have had, a blood clot (such as deep vein thrombosis or a pulmonary embolism)
  • Have, or have had, liver problems
  • Have been diagnosed with a bleeding disorder 
  • Have untreated thickening of the womb lining (endometrial hyperplasia)
  • Have a rare blood called porphyria
  • Are allergic to any of its listed ingredients
  • Are, or think you might be, pregnant 

Medication interactions – taking Vagifem can interfere with the effects of other medicines, and vice versa, sometimes causing irregular bleeding. Ask your doctor for advice before taking Vagifem if you are currently using: 

  • Medication for epilepsy (like phenytoin, phenobarbital and carbamazepine)
  • Medication for tuberculosis (like rifabutin and rifampicin) 
  • Medication for HIV infection (like efavirenz, neviraphine, nelfinavir and ritonavir)
  • Any herbal remedy containing St. John’s Wort (hypericum perforatum)

Vagifem comes in one dose – 10mcg. This is a fixed, low dose because it is a local form of treatment.  You should use oestrogens at the lowest dose possible, and only for as long as needed. Sudden or drastic changes in your hormonal levels can have far-reaching effects to your health, and should be properly considered.

How long in a course? – your doctor will talk things through with you to decide how long you should remain on treatment. If you stop taking Vagifem and your symptoms return, they may prescribe it again, with a full consideration of your treatment options and personal health risk.

Dosing instructions – the standard treatment instructions for Vagifem is to insert 1 tablet into the vagina per day for the first 2 weeks, afterwards taking 1 tablet twice a week (leaving 3 or 4 days between each dose).

Overdosing – if you ever use more Vagifem than you should, you should talk to your GP or a pharmacist for advice. Try to stick to the recommended dose, or whatever your doctor has prescribed.

Forgetting a dose – if you ever forget to use Vagifem, you should use the medicine as soon as you remember. Don’t ever double up on your dose to make up for your missed one. 

As with any medicine, there is a chance of getting some side effects as a result of taking Vagifem.

The most common side effects (affecting up to 1 in 10 people) are: 

  • Headaches
  • Abdominal cramps or stomach pain
  • Irregular vaginal bleeding (spotting), discharge or discomfort

Uncommon side effects (affecting up to 1 in 100 people) are: 

  • Feeling sick (nausea) or vomiting
  • Vaginal yeast infection or fungal infection
  • Weight increase
  • Hot flushes

Very rare side effects (affecting up to 1 in 10,000 people) include: 

  • Fluid retention
  • Diarrhoea
  • Allergic reaction (hypersensitivity, e.g. anaphylactic shock)

Other side effects that have been reported from Vagifem include

  • Breast pain
  • Bloating
If you ever experience severe or unpleasant side effects as a result of taking Vagifem, you should stop taking it immediately and seek urgent medical attention. You can report any side effects not listed here or in your medicine leaflet directly via the Yellow Card Scheme ( This will help improve knowledge of the medicine for other users and medical professionals.

Womb cancer – the main risk that comes from taking oestrogen hormones is that doing so can slightly increase your chance of getting cancer of the uterus (womb). If you experience any unexpected or unusual vaginal bleeding while you’re using Vagifem, you should contact your nurse or GP right away.

Blood clotting problems – taking oestrogen on its own can also increase your chances of getting a blood clot or having a stroke. Using oestrogen with progesterone can increase your chances of getting a blood clot, having a stroke, having a heart attack or developing breast cancer. Taking oestrogen with or without progesterone may also increase your chance of getting dementia.

You should stop using Vagifem and see a doctor immediately if you notice any of the following symptoms:

  • Migraine-like headaches, if you’ve never experienced them before
  • Yellowing of the skin or the whites of your eyes (jaundice), which could be a sign of liver disease
  • The signs of a blood clot (e.g. painful swelling or redness of one leg, sudden chest pain, or difficulty breathing)

All of these could point to an emergency reaction or health risk, so you should take these seriously. 

Novo Nordisk A/S. [online]. Available at: [accessed 15th March 2018].

Novo Nordisk A/S (2017). Vagifem® 10 micrograms vaginal tablets. Electronic Medicines Compendium. [online] Available at: [accessed 15th March 2018].