Pack of 84 Kliovance 1mg/0,5mg estradiol/norethisterone acetate film-coated tablets

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Kliovance Tablets

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Kliovance is a kind of hormone replacement therapy (HRT) that contains the hormones progesterone and oestrogen. It’s an effective treatment for relieving symptoms that can develop in women after the menopause. Kliovance starts working quickly and you should see an improvement in your symptoms within 10-14 days.

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To place an order, fill in a brief questionnaire. One of our doctors will review your order and prescribe a suitable treatment. You will only be charged if treatment is prescribed.

Kliovance – 84 tablets £40

Price includes standard delivery or click and collect.

In a hurry? Choose Click and Collect and pick up your order after just 2 hours from a Superdrug Pharmacy.

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About Kliovance

Kliovance is a prescription-only medicine used to treat menopausal women who are experiencing hot flushes and other menopausal symptoms.

Oestrogen levels in the body drop during menopause. This can lead to symptoms such as hot flushes, night sweats, a reduced sex drive or vaginal dryness. Kliovance treats these symptoms by replacing the lost oestrogen and balancing your hormone levels.

How long does it take for Kliovance to work?

HRTs work very quickly to relieve symptoms you may be experiencing during the menopause. Most women start to notice an improvement in their symptoms within 10 to 14 days of starting treatment. This will differ from woman to woman.

If you’ve been taking Kliovance for over two weeks and notice no difference in your symptoms, talk to your GP.

How effective is Kliovance?

Kliovance is very effective in treating a range of symptoms women experience in the menopause such as hot flushes, night sweats, insomnia, vaginal dryness, irritability, and depression.

Swallow Kliovance tablets whole with a glass of water, with or without food. It does not matter what time you take your dose, but make sure you take it at the same time every day.

How often should I use Kliovance?

You should take Kliovance once a day. If you forget a dose, you can still take it if it’s been less than 12 hours since you were supposed to take it. If it’s been more than 12 hours since you were supposed to take your dose, skip that dose. Do not take two doses of Kliovance in the same day.

How long do I use Kliovance for?

There’s no limit to how long you can take HRTs like Kliovance, but you should talk to your doctor about how long it is recommended to take Kliovance for. Most women only need to take it for a few years, until their menopause symptoms eventually go away.

Can I buy Kliovance online?

Yes, you can order Kliovance through Superdrug Online Doctor. You simply need to fill out an online questionnaire, which is then reviewed by one of our doctors to make sure Kliovance is a suitable treatment for you. If your order is approved, your Kliovance can be sent directly to you, or to your local Superdrug Pharmacy for you to pick up.

Can I buy Kliovance over the counter?

Yes, a pharmacist may sell you Kliovance without a prescription. Here at Superdrug Online Doctor you can order online and if our doctors agree it is a suitable treatment for you, it can be sent directly to your door. You can also pick it up from your local Superdrug store if that works better for you.

Can I get Kliovance on the NHS?

Yes, you can get Kliovance on the NHS after you have been prescribed it from your doctor.

Kliovance is a widely used HRT, and many women who take it will not get any side effects. But, just like any medication, there will be some who do.

Common side effects include:
  • headaches
  • itchiness or dryness of the vagina
  • feelings of depression
  • nausea
  • tender or swollen breasts
  • back pain
  • fluid retention
  • a vaginal infection

Uncommon side effects include:
  • bloating
  • acne
  • hair loss (alopecia)
  • leg cramps
  • allergic reaction
  • feelings of anxiety

Rare side effects include:
  • ovarian cancer
  • high blood pressure
  • Jaundice
  • gall bladder disease
  • blood clots
  • vomiting
  • insomnia

Kliovance and weight loss/gain

There is no research that has linked Kliovance and weight gain or loss. However, there have been reports by women who claim that they have gained or lost weight while taking the HRT. 

Kliovance and bleeding

You may have irregular vaginal bleeding or spotting during the first three to six months of taking Kliovance. However, this usually stops after the six month mark. If you continue to experience vaginal bleeding after this time, make an appointment to see your GP.

Kliovance and hair loss

There has been no research that has linked Kliovance to hair loss. However, there have been reports by women who claim to have experienced this while taking the HRT.

What do I do if I get Kliovance side effects?

Kliovance is used widely and many women report having no side effects at all. However, if your side effects do not get better after a few weeks, get in touch with your GP.
Kliovance is an effective HRT, but may not be right for everyone. Certain conditions can interact with Kliovance and make it less effective, or potentially unsafe.

Do not take Kliovance if you have, or have had:
  • breast cancer
  • high blood pressure
  • blood clots
  • diabetes
  • gallbladder problems
  • vaginal bleeding
  • liver disease

Kliovance is known to interact with:

  • antidepressants like amitriptyline, butisol
  • hiv medications like atazanavir
  • medicines used to treat epilepsy like carbamazepine
  • St. John’s wort
  • antibiotics like ciprofloxacin or rifampin
  • diltiazem (used to treat high blood pressure)
  • antifungal medicines like fluconazole or itraconazole
Tell your doctor about any medication you are taking before starting your treatment with Kliovance.

HRT comes in different forms such as gels, tablets and creams. The type of HRT your doctor prescribes will vary depending on if you are postmenopausal, and if you still have a womb. Alternatives to Kliovance include.

  • Vagifem
  • Vagirux
  • Elleste Duet
  • Estriol
  • Ovestin
  • Evorel Conti
  • Premique

Is Kliovance the same as Kliofem?

Kliovance and Kliofem are very similar: they are both oral tablets used to treat symptoms of the menopause with the same type of hormones. However, Kliofem contains double the amount of estradiol and progestogen than Kliovance. This means that Kliofem is much stronger than Kliovance, so you may be prescribed Kliofem if Kliovance doesn’t work for you.

Reviewed by: Dr Babak Ashrafi in line with the Superdrug Online Editorial Process.

GMC no. 6077866

Dr Ashrafi studied at King’s College London and specialises in cardiology, diabetes, and stroke medicine.

Last reviewed on: 09/11/21