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Order Tetralysal (Lymecycline) and Epiduo

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Tetralysal is a medication for acne. It contains the antibiotic lymecycline, which fights bacteria improves the look of your skin. It needs to be taken for several weeks in order to take visible effect. Epiduo is a topical gel that help treat acne symptoms.

To buy Tetralysal and Epiduo online, you need a prescription. You can get both a prescription and medication using our convenient online doctor service. Just fill in our brief assessment questionnaire and choose your preferred treatment. Our doctor will use your answers to check which treatment is suitable for you, just like your GP would. You will need to upload a photograph of the affected skin area, so our online doctor can assess your skin condition.

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To place an order, fill in a brief questionnaire. One of our doctors will review your order and prescribe a suitable treatment.


Tetralysal and Epiduo - 3 month £60

Prices include prescription and delivery. Product packaging may differ from image above.

In a hurry? Choose Click and Collect and pick up your order after just 3 hours from a Superdrug Pharmacy.

Delivery options

Delivery method Cost Estimated delivery

You will choose your delivery option at the checkout. Delivery options may vary depending on the pack size and dosage chosen.

Tetralysal (Lymecycline) Capsules and Epiduo Gel for Acne
Tetralysal is a branded medication which contains the antibiotic lymecycline. Lymecycline belongs to the group of tetracycline antibiotics. It can be prescribed for a range of bacterial infections but is most commonly used to treat acne vulgaris. Acne is caused by bacteria called propionibacterium acnes, which live on your skin. They live of excess sebum your skin produces and cause inflammation, whiteheads and spots. In some cases, they can also cause the development of large cysts. Lymecycline kills acne bacteria and allows your skin to recover from inflammation and bacterial infection. 

We only offer lymecycline with Epiduo because it’s recommended by NICE and the PCDS to only offer antibiotics with topical creams.
Acne treatment with tetralysal involves a standard course of three months, during which you will be taking one tablet daily. Each tetralysal tablet contains 300mg of lymecycline, the active substance. You should follow the course as prescribed by your doctor unless you suffer from side effects. It takes time for acne to respond to antibiotic treatment, which is why lymecycline is taken for three months. You should notice a significant improvement within this time frame.
You should take your daily lymecycline tablet every morning with a glass of water. If you have forgotten one dose of Tetralysal, just take it as soon as you remember. If it is almost time for the next capsule, just take one. Do not take two capsules at the same time to make up for a missed dose.

Epiduo gel contains 0.1% adapalene and 2.5% benzoyl peroxide. You use it once a day and apply a thin layer of gel to your acne symptoms.
When you order Tetralysal from Superdrug, our online doctor will make sure the antibiotic is suitable for you. It is important that you answer all questions on our assessment questionnaire correctly and carefully, as lymecycline and other tetracycline antibiotics are not suitable for everyone.

You can not take Tetralysal, if you:

  • are allergic to lymecycline or any other tetracycline antibiotic
  • are allergic to any other ingredient in Tetralysal
  • have kidney disease
  • are pregnant or breastfeeding
  • are trying for a baby

Tell your doctor before taking lymecycline tablets if you:

  • have ever had a liver problem
  • have been diagnosed with systemic lupus erythematosus or Myasthenia Gravis
You may not be able to use Epiduo if you’re pregnant, breastfeeding, or need to spend a lot of time in direct sunlight.
The active ingredient in Tetralysal (lymecycline) can interact with certain other medications. Tell your prescribing doctor about any medications you are taking or have recently taken before beginning treatment with lymecycline. This includes over the counter medicines and natural remedies.

Make sure you tell your doctor if you are taking:

  • medication to thin your blood (for example Warfarin)
  • diuretics
  • any other acne medication

Lymecycline interacts with hormonal contraception and can render it ineffective. You may need to use additional protection while taking the antibiotic and for a week after your treatment has ended.

Do not take lymecycline if you are taking:

  • indigestion remedies
  • the high blood pressure medication quinapril
  • ulcer healing drugs
  • nutritional supplements containing aluminium, calcium, magnesium, iron or zinc
Epiduo can also react with some other medication. Make sure you mention all your current medications when ordering acne treatment.
Common side effects of Tetralysal

  • abdominal pain
  • feeling and being sick
  • diarrhoea
  • headache

For a full list of possible side effects read the patient leaflet supplied with your lymecycline tablets.

Stop taking tetralysal if you experience:

  • swellings of the face, throat or tongue
  • difficulty breathing
  • hives, blistering, peeling or skin rash
  • ulcers in the mouth or on your lips
  • ulcerations or lesions in the genital or anal area
  • visual disturbances
Epiduo can also cause side effects, including: redness, dryness, peeling, burning, stinging, scaling, swelling, itching, or your acne symptoms getting temporarily worse.