Differin Cream has a few side effects, mainly affecting the areas of skin where it’s applied. Side effects are more likely if you apply more cream than needed. If you get a lot of skin irritation, we suggest applying it less often until it settles down.
Common side effects of Differin Cream include:
- irritation, redness, or burning sensation at the site of application
- dry skin
Uncommon side effects of Differin Cream include:
- contact dermatitis (a local skin reaction)
- skin discomfort
- itching of the skin (pruritus)
- peeling skin
- acne flare-up
Rare side effects of Differin Cream include:
- a severe allergic reaction, which can make it difficult to swallow or breathe, and may cause a rash, itching, swelling, and dizziness
If you get a severe allergic reaction, you need immediate medical attention. Call 999 or get someone to take you to A&E straight away.
Other side effects have been reported but not enough to determine whether they are common, uncommon, or rare. These include:
- a mild allergic reaction at the site of application
- swelling or painful skin
- redness, irritation, itching, or swelling of the eyelids
- a change in skin colour, such as darkening of fair skin or lightening of darker skin
- burns at the application site
How long do Differin Cream side effects last?
Differin Cream side effects should only last a couple of weeks. If you get irritation, soreness, or burning that is affecting you for longer, or it irritates you a lot, speak to your doctor. Remove the cream with water if irritation continues after application.
What to do if you get Differin Cream side effects
If you get Differin Cream side effects that are mild and go away after application, continue treatment and monitor side effects. If your side effects are bothering you a lot and do not go away within a few weeks, speak to your doctor. They may recommend using the cream less often, or waiting until side effects go away before trying again.
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