Lisinopril treats high blood pressure by making it easier for your heart to pump blood around your body. It's an effective treatment that starts working within a few hours, but you need a couple of weeks to feel the full effect of the treatment. =

In stock
from £20.00

Product details

Lisinopril is an effective medication used to treat high blood pressure. It works by making it easier for your heart to pump blood around your body and should start working within a few hours of taking it, but you may need to wait a few weeks to notice its full effects. You can order lisinopril for high blood pressure from Superdrug Online Doctor, to help reduce the health risks that high blood pressure may cause.

Dr Louisa Draper

Medically reviewed by

Dr Louisa Draper

Last reviewed: 06 Dec 2021

Lisinopril prices

Pack Size Price
5 mg - 3 x 28 tablet(s) £20.00
10 mg - 3 x 28 tablet(s) £20.00
20 mg - 3 x 28 tablet(s) £20.00

How it Works

About Lisinopril for High Blood Pressure

What is lisinopril?

Lisinopril is a medicine that is prescribed to treat high blood pressure. It is also used to treat heart failure and kidney disease with diabetes. Lisinopril is usually taken as a tablet but can also be prescribed as a liquid.

How does lisinopril work?

Lisinopril works by making it easier for your heart to pump blood around your body. It is one of a group of medicines called angiotensin-converting enzyme (ACE) inhibitors. These medicines relax and widen your blood vessels, making it easier for blood to flow through your body.

Lisinopril will start to work within a few hours, but it can take several weeks for it to become fully effective. If you have high blood pressure you may not feel ill, so you might not notice any difference when taking lisinopril, but this does not mean that it is not working.

Levels of lisinopril in your body will start to drop 12 hours after you stop taking it. It will take around 2 to 3 days for your system to be completely clear of the medicine.

Is lisinopril a beta-blocker?

No, lisinopril is an ACE inhibitor. Beta-blockers are a different type of medicine that are used to treat chest pain, heart failure, irregular heartbeat, heart attacks and high blood pressure. Lisinopril and beta-blockers are sometimes used together to manage heart attacks and high blood pressure.

Lisinopril doses

Lisinopril is usually prescribed at a low dose to begin with. This is to reduce the side effects and to make sure you are prescribed the right dose. Your dose can then be increased over a few weeks if needed.

Lisinopril tablets come in the following doses:

  • 2.5mg
  • 5mg
  • 10mg
  • 20mg

The starting dose will usually be between 2.5mg and 5mg. This will be increased to up to 20mg daily for most adults. The maximum dose each day is 80mg, but your doctor will prescribe the right dose for you.

Where can I buy lisinopril?

Lisinopril is a prescription-only medicine which means you cannot buy it over the counter without a prescription. Lisinopril can be prescribed by your GP, and you can get it on the NHS, but you will need to make an appointment with your GP first. You can also order lisinopril from Superdrug Online Doctor using our online questionnaire, which means you do not have to leave your home to get your medication.

Once you have registered for an account with us and completed the questionnaire, our doctors will review your information to make sure lisinopril is safe for you to take. If approved, your prescribed medication will be sent to an address of your choosing, or you can pick it up from your local Superdrug pharmacy.

We offer 5mg, 10mg, and 20mg tablets for £20 for a 3-month course.

Lisinopril side effects

Like all medicines, lisinopril may cause some side effects. Not everybody gets them, and some people only get mild side effects. Side effects from taking lisinopril will usually go away on their own after a few weeks. If they don’t, or you have any concerns about the side effects, you should speak to your doctor.

Common side effects include:

  • a cough that will not go away
  • feeling dizzy – this is very likely when you first start taking lisinopril or when you change dose
  • headaches
  • being sick and/or diarrhoea
  • skin rashes and itching
  • blurring of your vision

These side effects are the ones that many people get when they first start to take lisinopril, but they should go away after some time. Rare side effects include:

  • skin or whites of the eyes turning yellow (jaundice) meaning that your liver is not functioning properly
  • feeling tired, dizzy, or fainting
  • paleness, bleeding, particularly from the gums, or bruising more easily
  • sore throat, fever, getting infections more easily - this means there could be a problem with your blood cells
  • a fast heart rate or tightness in your chest
  • breathing difficulties including wheezing and shortness of breath
  • very bad tummy pains
  • difficulty peeing, blood in pee, or swelling around your ankles
  • slurred speech or problems speaking, weakness in your arms and legs

Most people do not get rare or serious side effects from taking lisinopril. You should contact a doctor straight away if you get any of them. Feeling weak in your arms, legs, or having speech problems can be a sign of a stroke. You should call 999 for an ambulance right away.

Lisinopril can occasionally be linked to an allergic reaction called angioedema. This can cause swelling that may appear to be unexplained weight gain. You should call 999 or go to A&E straight away if you have this or any other signs of an allergic reaction.

What are the long-term side effects of lisinopril?

Lisinopril is normally prescribed for the long-term. It works best in this way to manage heart conditions and to keep blood pressure low. Lisinopril is considered safe to take for a long time and has few side effects when taken this way. As lisinopril has some effects on your kidneys, your doctor should check your kidney function regularly to make sure that they are working well.

Lisinopril and erectile dysfunction

Erectile dysfunction (difficulty in getting or keeping an erection) is not normally a side effect of taking lisinopril. However, high blood pressure itself may cause erectile dysfunction in some men. Treatment with ACE inhibitors has not been found to affect erectile dysfunction.

Does lisinopril cause weight gain?

Lisinopril is not known to cause weight gain in patients with high blood pressure, but having a high BMI can be a reason that some people develop problems with blood pressure.

Lisinopril warnings

Lisinopril can be affected by other medicines that you might take. You should always tell your doctor about other medications you use including:

  • over the counter medicines that you don’t need a prescription for
  • herbal medicines
  • any other prescription medicine you are taking

Lisinopril and Viagra

Viagra contains sildenafil which can lower your blood pressure. This can make it unsafe to take both Viagra and lisinopril together. If you experience problems getting or maintaining an erection and take lisinopril you should speak to a doctor about alternatives to Viagra.

Lisinopril and ibuprofen

Anti-inflammatory medicines like ibuprofen can interfere with lisinopril. You should speak to your doctor before using ibuprofen whilst taking lisinopril. Other painkillers like paracetamol should be fine to take with lisinopril.

What painkillers can I take with lisinopril?

Check with a doctor which painkillers are safe for you to use when taking lisinopril. Paracetamol and low doses of aspirin (no more than 75mg a day) are normally safe to take with lisinopril.

Lisinopril interactions

Before taking lisinopril you should tell your doctor if you are taking:

  • low blood pressure medication
  • other medicines for high blood pressure
  • any other medication that can lower your blood pressure, including antidepressants, nitrates, baclofen, anaesthetics, and medicine to treat an enlarged prostate gland
  • immunosuppressant drugs, such as ciclosporin or tacrolimus
  • diuretics, tablets to make you pee more often
  • medicines that raise the amount of potassium in your blood including spironolactone, triamterene, amiloride, potassium supplements, trimethoprim, and heparin)
  • a steroid medication called prednisolone
  • medicine for gout called allopurinol
  • procainamide
  • any medication for diabetes
  • diarrhoea medicines like racecadotril
  • lithium

Foods to avoid when taking lisinopril

You should avoid alcohol when you first start to take lisinopril or change dose. This is because alcohol can increase the effects of lisinopril and cause dizziness. If lisinopril makes you feel dizzy you should avoid alcohol.

Some foods contain high levels of potassium which can affect lisinopril. You should aim to eat a healthy, balanced diet if you have high blood pressure but avoid too much of the following food types:

  • bananas
  • oranges
  • potatoes
  • tomatoes
  • squash
  • dark leafy vegetables
  • salt substitutes

Lisinopril and grapefruit

Grapefruit and grapefruit juice can affect the way some medicines work but it has not been shown to affect ACE inhibitors like lisinopril.

Lisinopril alternatives

There are other ACE inhibitors apart from lisinopril. These include:

  • enalapril
  • captopril
  • ramipril
  • perindopril

Other types of medicines that lower blood pressure are:

  • calcium channel blockers
  • angiotensin receptor blockers
  • beta-blockers
  • diuretics – tablets to make you pee more often

Whilst most people can take lisinopril safely and without serious side effects, some people may need to use a different type of medicine to lower their blood pressure. Usually, your doctor will prescribe medicine from the group known as angiotensin receptor blockers (ARBs), like losartan.


ACE inhibitors, ARBs and the links with coronavirus (2020) British Heart Foundation [accessed 13 September 2021]

Angioedema – Symptoms (2019) NHS Online [accessed 13 September 2021]

Beta-blockers with ACE inhibitors – a logical combination? (1989) PubMed [accessed 13 September 2021]

Drug interactions between lisinopril and Viagra (2021) [accessed 13 September 2021]

Lisinopril (2018) NHS Online [accessed 13 September 2021]

Lisinopril (2021) NICE [accessed 13 September 2021] Lisinopril (2021) NCBI [accessed 13 September 2021]

Lisinopril oral tablet: Side effects, dosage, interactions and more (2021) Medical News Today [accessed 13 September 2021]

Medicinal importance of grapefruit juice and its interaction with various drugs (2007) NCBI [accessed 13 September 2021]

Potassium the nutrition source (2021) Harvard T.H. Chan School of Public Health [accessed 13 September 2021]

Sildenafil (Viagra) (2019) NHS Online [accessed 13 September 2021]

The effect of antihypertensive drugs on erectile function: a proposed management algorithm (2006) PubMed [accessed 13 September 2021]

Patient Reviews