Side Effects of ellaOne: What to Expect After Taking It

headshot of medical editor brenda Ikeji

Medically reviewed by

Dr. Ikeji

Last reviewed: 18 Nov 2025

ellaOne is a branded type of emergency contraception, also known as the morning after pill, that contains the active ingredient ulipristal acetate. It’s taken to prevent pregnancy if you have had unprotected sex or your contraceptive method has failed, like you missed your pill or a condom broke.

ellaOne can cause side effects in some people, and it is important to know what they are so that you can manage them effectively. The side effects can also be similar to the early signs of pregnancy. Understanding how long ellaOne side effects last may help you recognise the difference between side effects and a potential pregnancy.

In this guide, we explore the common, uncommon, and rare side effects of ellaOne, how long they last, and what you can do to manage them safely at home.

Box of ellaOne tablets on a purple background

How does ellaOne work?

ellaOne’s active ingredient, ulipristal acetate, works by delaying or preventing the release of an egg from the ovaries (ovulation). It does this by binding to progesterone receptors to stop the hormone from attaching to its receptors, which causes ovulation.

ellaOne is most effective if it is taken before ovulation happens, as it cannot prevent pregnancy if an egg has already been released. One of the advantages of ellaOne is that it can be taken up to 5 days after unprotected sex has occurred, compared to other morning after pills that contain levonorgestrel, such as Levonelle, which only remain effective for up to 3 days.

Research shows that ellaOne is 98% effective if it is taken up to 120 hours after unprotected sex.

Common side effects of ellaOne

Any medication has the potential to cause side effects, including ellaOne. These side effects can be split into common, uncommon, and rare, depending on how many people get them.

The most common ellaOne side effects, affecting up to 10% of people, are:

  • feeling sick (nausea)
  • stomach pain or discomfort
  • being sick
  • painful periods
  • pelvic pain
  • breast tenderness
  • headache
  • dizziness
  • mood swings

You may notice that your next period after taking ellaOne is lighter, heavier, earlier, or later than usual.

Less common or rare side effects

Some of the less common side effects, affecting up to 1 in 100 people, include:

  • unusual or irregular vaginal bleeding
  • appetite changes
  • mood changes
  • acne
  • sleep changes

Rarely, in 1 in 1,000 people, ellaOne can cause:

  • genital pain or itching
  • loss of concentration
  • fainting
  • thirst
  • unusual sensations in the eye
  • taste changes

Although these side effects can be unpleasant or uncomfortable, they usually only last a short while and are not usually a cause for concern.

You can find a full list of ellaOne side effects in the patient information leaflet.

Do side effects mean ellaOne has worked?

The only way to know if ellaOne has worked is when your next period arrives. Experiencing side effects is not a sign that it has worked, especially as many of these side effects are also similar to signs of pregnancy.

Side effects are caused by your body interacting with the medication, and not a sign that it is working or not working.

If your next period after taking the morning after pill is unusually heavy or light, is more than 7 days late, or you are experiencing symptoms, such as breast tenderness, feeling or being sick, or stomach pain, you could be pregnant. In this case, you should take a pregnancy test.

How long do ellaOne side effects last?

If you get side effects from taking ellaOne, they typically last only a few hours to a few days and are usually mild.

However, if you vomit within 3 hours of taking ellaOne, it will not be effective, and you will need to take another pill.

If side effects last for more than a few days, you should contact your doctor for more advice or consider taking a pregnancy test.

Does ellaOne affect your period?

Yes, ellaOne can affect your period after you take it by making it come earlier or later, or by changing how heavy it is or how long it lasts. The active ingredient, ulipristal acetate, temporarily affects the hormonal balance that regulates your menstrual cycle by delaying ovulation.

The hormonal changes caused by ellaOne can affect your cycle and next period, but it should return to normal the following month.

Managing side effects of ellaOne

Most ellaOne side effects are mild and temporary and can be managed at home. The most common side effects are feeling or being sick. If you vomit within 3 hours of taking ellaOne, you should contact your doctor or pharmacist because you will need to take another dose.

You can manage feeling or being sick by:

  • eating smaller, more frequent meals
  • avoiding spicy, greasy, or fatty foods
  • taking regular sips of water or ginger, peppermint, or camomile tea
  • not lying down after you have eaten
  • getting fresh air and going for a gentle walk outside

If you are experiencing headaches, you can try:

  • getting rest until it passes
  • reducing your screen time or using blue light-blocking glasses
  • taking frequent sips of water to avoid dehydration
  • taking over-the-counter painkillers, such as paracetamol or ibuprofen

If you get stomach cramps, you can help relieve them by:

  • getting plenty of rest
  • holding a warm compress or heat pad over your stomach
  • taking over-the-counter painkillers
  • trying gentle exercise, like yoga or walking
  • staying hydrated
  • prioritising good quality sleep

If you find any side effects difficult to manage or are concerned, contact your doctor or pharmacist for more advice.

When to see a doctor

You should see a doctor after taking ellaOne if:

  • your period is more than 7 days late
  • you get severe abdominal pain or heavy bleeding
  • your symptoms are persistent or getting worse

If you vomit within 3 hours of taking it, speak to the doctor or pharmacist who prescribed ellaOne about whether you need a new pill.

In rare cases, ellaOne can cause an allergic reaction. If you experience any of the following symptoms, you should call 999 or get someone to take you to A&E because this requires immediate medical attention:

  • difficulty breathing or wheezing
  • swelling of tongue, lips, throat
  • sudden fainting
  • dizziness or lightheadedness
  • clammy skin
  • swelling of face, lips or eyes
  • nausea, vomiting or diarrhoea
  • confusion
  • red, raised and/or itchy rash

If you get any ellaOne side effects, including any that are not listed in the patient information leaflet, and they cause you any concern, contact your doctor or pharmacist for more advice.

FAQs

Does ellaOne affect fertility or future periods?

No, ellaOne does not affect long-term fertility – it only affects the cycle you’re in when you take it. That means you may notice your next period is lighter or heavier, or earlier or later than usual, but any periods after should not be affected.

Can I take ellaOne more than once in a cycle?

Yes, you can take ellaOne twice in the same cycle, but it’s not recommended for regular use. If you need to take it more than once in a cycle, or more regularly, then you should speak to a doctor or pharmacist about a more long-term method of contraception.

What should I do if I have severe side effects after taking ellaOne?

If you experience severe side effects after taking ellaOne, you should speak to a doctor or 111 straight away. If you notice any signs of an allergic reaction, such as a skin rash, swelling of the lips, tongue, or face, or severe stomach pain, call 999 or get someone to take you to A&E. For less severe side effects, like being sick, contact your doctor or pharmacist if you are concerned.

When do ellaOne side effects start?

ellaOne side effects can start within a few hours of taking it and can last a few days until the medication has been cleared by your system. Not everyone will get ellaOne side effects, but if you get prolonged side effects like feeling or being sick, these could be signs of pregnancy, and you should consider a pregnancy test or speaking to your doctor.

Sources

Patient Reviews